Mohamad-Ali Salloum is a Pharmacist and science writer. He loves simplifying science to the general public and healthcare students through words and illustrations. When he's not working, you can usually find him in the gym, reading a book, or learning a new skill.
The Science of Staying Hungry: Ramadan's Hidden Health Benefits Explained
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For generally healthy adults, Ramadan’s dawn‑to‑sunset fast is associated with small but meaningful improvements in weight, lipids, blood pressure, and fasting glucose—plus mental well‑being gains—provided that nights are used smartly for hydration, nutrition, sleep, and medications. Patients with diabetes, hypertension, CKD, older age, or polypharmacy can often fast safely only with individualized risk stratification, education, and dose‑timing adjustments. This article translates high‑grade evidence into practical, enjoyable guidance you can use at the counter, in clinics, or on rounds.
The Physiology—Explained Simply
Think of Ramadan fasting as a daily metabolic “reset”: daytime is “maintenance mode” (low insulin, fat mobilization), night is “refuel and repair” (insulin rises, glycogen refills, proteins rebuild). In practice, that rhythm:
- nudges body weight and waist circumference down a little,
- trims triglycerides and total cholesterol while nudging HDL up,
- modestly lowers systolic/diastolic blood pressure, and
- slightly improves fasting glucose.
These are not crash‑diet effects; they’re small, consistent shifts seen across meta‑analyses of Ramadan fasting (a diurnal, dry intermittent fasting model distinct from water‑fast TRE) and umbrella reviews of intermittent fasting RCTs. [cambridge.org], [academic.oup.com], [bmj.com]
At the same time, meal timing (chrononutrition) matters: earlier energy intake and shorter eating windows align better with circadian biology and can amplify weight‑loss and glycemic benefits observed in longer‑term RCTs of time‑restricted eating. While Ramadan isn’t exactly TRE (because it’s dry and socially unique), the principle that timing matters still helps your counseling around Suhoor/Iftar. [jamanetwork.com], [ahajournals.org]
What Changes During Ramadan? Evidence in Plain Language
1) Cardiometabolic Risk Factors
Weight & Waist: Meta‑analyses show small decreases in weight and waist circumference among healthy adults. Example: an umbrella review of meta‑analyses found standardized mean differences of ~–0.3 to –0.34 for weight and waist. Translation: expect ~1–2 kg reduction in many adults. [academic.oup.com]
Lipids: Modest reductions in LDL‑C, total cholesterol, triglycerides, with small uptick in HDL. Effects vary with what people eat at night (dates + fried foods vs. balanced plates). [academic.oup.com], [nmcd-journal.com]
Blood Pressure: Systolic and diastolic BP fall by ~3–4 mmHg on average across observational cohorts and meta‑analyses (London Ramadan Study + pooled data). [ahajournals.org], [nutrition.bmj.com]
Glucose: Small improvements in fasting glucose for healthy adults; in diabetes, glycemia can swing without counseling/adjustments (see dedicated section). [academic.oup.com]
Clinic pearl: These shifts are similar in direction—but smaller in magnitude—than what we see with standard weight‑loss or Mediterranean‑style diets. Reinforce quality of the Iftar/Suhoor plate to unlock the benefit. [bmj.com]
2) Mental Health, Sleep, and Cognition
Systematic reviews report improvements in anxiety, stress, and psychological well‑being during Ramadan, but sleep quality can worsen if nights are short or fragmented—often due to late social meals and dawn wake‑ups. Encourage a consistent sleep plan and caffeine taper. [link.springer.com], [researchgate.net]
3) Gut Microbiome
Human studies suggest Ramadan fasting can increase microbial diversity and favor taxa linked to metabolic health (e.g., Faecalibacterium, sometimes Akkermansia), though findings are heterogeneous and diet quality remains a major driver. Bottom line: better plates = better bugs. [academic.oup.com], [jstage.jst.go.jp]
“Make‑It‑Stick” Counseling: 10 Practical Tips for Healthy Adults
- Build the Iftar: Break fast with water + 1–2 dates; then a vegetable‑heavy plate, lean protein (fish, chicken, legumes), whole‑grain starch (bulgur, brown rice), and olive oil. Keep fried items and sweets as small “tastes,” not the main act. (Helps lipids/glucose) [bmj.com]
- Respect Suhoor: Eat a late Suhoor rich in protein + fiber + fluids (e.g., eggs, Greek yogurt, oats, fruit, nuts, plenty of water). Earlier vs. later Suhoor timing may influence daytime alertness; later Suhoor sometimes supports steadier energy. [frontiersin.org]
- Hydrate by the clock: Target clear urine by bedtime; separate caffeinated drinks from main hydration. (Supports BP and cognition) [ahajournals.org]
- Move smart: Light‑to‑moderate activity pre‑Iftar; resistance training 1–3 h after Iftar when fueled. Sprint efforts may dip in the morning; endurance is relatively preserved. [link.springer.com]
- Sleep in blocks: Aim for 7–8 h total using split sleep (core night + post‑Fajr nap). This offsets REM reduction and subjective sleepiness reports in less controlled environments. [researchgate.net]
- Supplements: If diet is limited, consider vitamin D, calcium (as per baseline status), and a general multivitamin—especially in older adults or restrictive eaters. (General practice advice; not Ramadan‑specific trial data.)
- Caffeine strategy: Taper pre‑Ramadan to avoid withdrawal headaches in week 1; time caffeine shortly after Iftar to avoid insomnia. [thieme-connect.com]
- GI care: For reflux, split Iftar into two small meals (maghrib + later), avoid deep‑fried/fatty foods, elevate head of bed. (Expert practice aligned with circadian/chrononutrition evidence) [ahajournals.org]
- Plate discipline at social gatherings: Open with salad/soup; keep dessert to 2–3 small bites. Tie advice to small but real lipid/glucose gains. [academic.oup.com]
- Post‑Ramadan plan: Keep an earlier eating window a few days per week to preserve weight and BP benefits. [jamanetwork.com]
Special Populations: What to Do Before You Say “Yes, You Can Fast”
Golden rule: Risk‑stratify 6–8 weeks before Ramadan, educate, and tailor the plan. The IDF‑DAR Practical Guidelines remain the clinical backbone, with an updated risk calculator in 2026 offering refined thresholds (low, moderate, high risk). [idf.org], [thieme-connect.com]
A) Diabetes (Type 1 & Type 2)
Is fasting allowed?
- Type 1: usually high‑risk; many should not fast. Select well‑controlled, technology‑savvy patients may fast with CGM, education, and close monitoring.
- Type 2: many can fast with pre‑Ramadan education and therapy adjustments.
Key steps for pharmacists and trainees
- Risk score (IDF‑DAR): consider A1C, hypoglycemia history, CKD, pregnancy, work intensity, fasting hours. High‑risk → advise against fasting; offer fidya alternatives. [idf.org]
- Structured education: SMBG/CGM does not break the fast; teach when to break (BG <70 mg/dL [3.9 mmol/L], >300 mg/dL [16.7 mmol/L], symptomatic hypo/hyperglycemia, dehydration). [idf.org]
Therapy adjustments (examples):
- Metformin: same dose; shift to Iftar ± Suhoor.
- SGLT2 inhibitors: caution in hot climates/long fasts due to euglycemic DKA/dehydration risk; consider pausing in high‑risk.
- Sulfonylureas: reduce dose and give with Iftar (highest hypo risk).
- DPP‑4, GLP‑1RA: generally favorable; align with Iftar.
- Basal insulin: reduce 15–30%; titrate to fasting SMBG; avoid “stacking”.
- Basal‑bolus: move prandial to Iftar/Suhoor, reduce doses, and emphasize correction factors + SMBG.
(Doses individualized per IDF‑DAR tables and local guidelines.) [idf.org], [rightdecis…cot.nhs.uk]
What to expect: With good education, many patients avoid excess hypoglycemia and may even improve A1C over subsequent months; without it, hyperglycemia around Iftar feasts is common. [idf.org]
B) Hypertension
What the data say: Meta‑analyses and cohort data suggest modest BP reductions (~3–7 mmHg), including in those with hypertension—provided night‑time hydration and adherence to meds. Evidence in CKD is less consistent. [ahajournals.org], [e-journal….nair.ac.id]
Medication timing
- Prefer once‑daily evening dosing (Iftar) for ACEI/ARB/CCB where feasible.
- Morning diuretics can worsen daytime hypohydration; consider moving thiazides to Iftar or using non‑diuretic regimens if volume depletion is a concern; monitor electrolytes. [onlinelibr….wiley.com]
Counseling scripts:
- “If you feel dizzy standing up, break the fast, rehydrate, and call us.”
- “Aim for 2+ liters of fluids between Maghrib and Suhoor unless restricted.”
C) Chronic Kidney Disease (CKD)
Bottom line: Assess stage + comorbidities + season length. Low‑to‑moderate risk CKD patients may fast with a plan (labs before and mid‑Ramadan, hydration strategy, med review). High/very high risk (eGFR <30, unstable disease, recent AKI, transplant <1 year) should avoid fasting and consider alternatives. [link.springer.com], [academic.oup.com]
What to watch: dehydration → prerenal azotemia, electrolyte shifts, AKI triggers (ACEI/ARB + diuretics + NSAIDs). Night hydration strategies and medication timing are crucial. Evidence syntheses in 2024 provide consensus frameworks (RaK Initiative). [link.springer.com]
D) Older Adults (≥65–70 years), Frailty, Polypharmacy
Evidence snapshot: Small studies suggest potential psychological benefits, but risks include dehydration, orthostatic hypotension, falls, and sleep disruption—especially in week 1 before physiologic adaptation. Use IDF‑DAR risk elements (frailty, support at home) and monitor closely. [link.springer.com], [canberrais…tre.org.au]
Practical guardrails
- Prioritize Suhoor (protein, fiber, fluids).
- Split Iftar to reduce post‑prandial hypotension.
- Review fall‑risk meds (alpha‑blockers, sedatives).
- Arrange check‑ins (BP, weight, hydration signs) in week 1 and 3.
Cardiovascular Patients: Safety Signals and Nuance
Guidance from cardiology experts suggests stable cardiac disease patients (stable angina, controlled HF) often fast safely with clinician oversight; unstable conditions should avoid fasting. Observational data show neutral to favorable risk during Ramadan, with some cohorts noting a rise in AMI incidence in the month after Ramadan, possibly due to rebound behaviors or sleep changes—use this to reinforce sustained healthy routines. [heart.bmj.com], [mdpi.com]
Athletic & Active Patients
Meta‑analysis shows aerobic performance is generally maintained, while morning sprint power may decline; schedule high‑intensity sessions after Iftar and keep sleep/nutrition tight. For strength athletes, anchor protein (1.6–2.2 g/kg/d) across Iftar‑to‑Suhoor with two to three high‑quality feedings. [link.springer.com]
Case Vignettes You Can Use Tomorrow
- The “well‑controlled T2D” teacher on metformin + GLP‑1RA with A1C 7.2%: low‑to‑moderate risk. Educate on SMBG, shift metformin to Iftar + Suhoor, maintain GLP‑1RA schedule, create a CGM alert plan, and define break‑the‑fast rules. Expect manageable glycemia if Iftar is balanced. [idf.org]
- The “thiazide‑treated HTN” shopkeeper: move HCTZ dose to Iftar, emphasize 2–2.5 L water between Maghrib and Suhoor, add potassium‑rich foods (if not CKD), and set up a 2‑week BP check. [ahajournals.org], [onlinelibr….wiley.com]
- The CKD G3a retiree on ACEI: preseason labs, counsel on break‑signals (cramps, dizziness, low urine output), liberalize nocturnal fluids, avoid NSAIDs, repeat creatinine/K+ at day 10–14. If Ramadan is in hot, long‑day months, consider religious exemptions. [link.springer.com]
What to Say When Patients Ask “Does Fasting Break If I…?”
- Check blood glucose? No—SMBG/CGM does not break the fast. [idf.org]
- Use inhalers, eye drops, or skin patches? Generally does not break the fast; defer religious rulings to local scholars, but medical consensus is permissive. (Align counseling with local practice alongside IDF‑DAR.) [idf.org]
The Joyful Part: Make Ramadan Healthy and Enjoyable
Elevate the social table: Lebanese mezze can be gloriously heart‑healthy—fattoush with olive oil, hummus, grilled fish, mujaddara—if fried items and syrups are small accents.
Micro‑habits: Pre‑Iftar 10‑minute walk, mindful eating for 15 minutes, then seconds if still hungry; a warm herbal tea at Suhoor can soothe reflux and encourage fluids.
Keep the spirit: Encourage families to plan “balanced Iftar nights”—celebratory yet moderate.
References:
- Faris ME, Jahrami H, Alsibai J, Obaideen AA. Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non‑athletic Muslim people: a systematic review and meta‑analysis. Br J Nutr. 2020;123(10):1–17. [cambridge.org]
- Jahrami H, Ammar A, Glenn JM, et al. An umbrella review and meta‑analysis of meta‑analyses of the impact of Ramadan fasting on metabolic syndrome components. Nutr Rev. 2024;83(2):e711–e721. [academic.oup.com]
- Semnani‑Azad Z, Khan TA, Chiavaroli L, et al. Intermittent fasting strategies and cardiometabolic outcomes: network meta‑analysis of randomized trials. BMJ. 2025;389:e082007. [bmj.com]
- Al‑Jafar R, Themeli MZ, Zaman S, et al. Effect of Ramadan fasting on blood pressure: LORANS cohort and meta‑analysis. J Am Heart Assoc. 2021;10:e021560. [ahajournals.org]
- Gholampoor N, Sharif AH, Mellor D. Religious fasting and cardiovascular risk: systematic review & meta‑analysis. BMJ Nutr Prev Health. 2024;7(Suppl 1):A4.2. [nutrition.bmj.com]
- Ahmed DR, Al Azzawi M, Ahmed JO, et al. Systematic review: mental health benefits of Ramadan fasting. Discover Psychology. 2026;6:2. [link.springer.com]
- Qasrawi SO, Pandi‑Perumal SR, BaHammam AS. Ramadan fasting and sleep, cognition, circadian rhythm: review. Sleep Breath. 2017;21(3):555–68. [researchgate.net]
- Pieczyńska‑Zając JM, Malinowska A, Łagowska K, et al. TRE and Ramadan fasting: effects on gut microbiota—a systematic review. Nutr Rev. 2024;82(6):777–93. [academic.oup.com]
- Pramono A, Ardiaria M, Limijadi EKS, et al. Intermittent fasting modulates human gut microbiota: systematic review. Biosci Microbiota Food Health. 2024;43(3):170–82. [jstage.jst.go.jp]
- International Diabetes Federation; Diabetes and Ramadan (DAR) International Alliance. Diabetes and Ramadan: Practical Guidelines. Brussels: IDF; 2021. (Accessed July 2024 via IDF). [idf.org]
- NHS Greater Glasgow & Clyde. Diabetes Mellitus During Ramadan: Guideline (v6). 2024. [rightdecis…cot.nhs.uk]
- Afandi B, Suliman M, Shaikh S, et al. The 2026 Update of the IDF‑DAR Risk Calculator for fasting in people with diabetes. J Diabetes Endocr Pract. 2026;9(1):20–8. [thieme-connect.com]
- Boobes Y, Afandi B, AlKindi F, et al. Consensus recommendations on fasting during Ramadan for patients with kidney disease (RaK Initiative). BMC Nephrol. 2024;25:84. [link.springer.com]
- Malik S, Bhanji A, Abuleiss H, et al. Effects of fasting on CKD during Ramadan and practical guidance. Clin Kidney J. 2021;14(6):1524–34. [academic.oup.com]
- Akhtar AM, Ghouri N, Chahal CAA, et al. Ramadan fasting: recommendations for patients with CVD. Heart. 2022;108(4):258–65. [heart.bmj.com]
- Betesh‑Abay B, Shiyovich A, Davidian S, et al. AMI outcomes and the Ramadan period. J Clin Med. 2022;11(17):5145. [mdpi.com]
- Abaïdia A‑E, Daab W, Bouzid MA. Effects of Ramadan fasting on physical performance: systematic review & meta‑analysis. Sports Med. 2020;50:1009–26. [link.springer.com]
- Liu HY, Eso AA, Cook N, et al. Meal timing strategies and metabolic outcomes: systematic review and meta‑analysis of RCTs ≥12 weeks. JAMA Netw Open. 2024;7(11):e2442163. [jamanetwork.com]
- Dashti HS, Jansen EC, Zuraikat FM, et al. Advancing chrononutrition for cardiometabolic health: NHLBI workshop report. J Am Heart Assoc. 2024;13:e039373. [ahajournals.org]
- Tezcan H, Büyükterzi Z. Ramadan fasting, BP, and kidney function in newly diagnosed HTN: observations. J Clin Hypertens. 2025;27(…):e70159 (Letter). [onlinelibr….wiley.com]
- Bougrine H, Ammar A, Trabelsi K, et al. Suhoor timing and cognition during Ramadan in athletes. Front Nutr. 2024;11:1373799. [frontiersin.org]
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Mohamad-Ali Salloum, PharmD
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